Am Fam Physician. 2007 Jan 15;75(2):194-202.
Patient information: See related handout on patellofemoral pain syndrome, written by the authors of this article.
Patellofemoral pain syndrome (PFPS) is the most common diagnosis in outpatients presenting with knee pain. Studies have shown PFPS to be the most common single diagnosis among runners and in sports medicine centers.1,2 Eleven percent of musculoskeletal complaints in the office setting are caused by anterior knee pain (which most commonly results from PFPS), and PFPS constitutes 16 to 25 percent of all injuries in runners.1,3,4 The diagnosis of PFPS is made clinically, and although management can be challenging, a well-designed, nonoperative treatment program usually allows patients to return to recreational and competitive activities. The following provides an update on the clinical evaluation and treatment of patients with PFPS.
Definition
The term “PFPS” is often used interchangeably with “anterior knee pain” or “runner’s knee.” PFPS can be defined as anterior knee pain involving the patella and retinaculum that excludes other intraarticular and peri-patellar pathology.5 Chondromalacia patellae, a condition in which there is softening of the patellar articular cartilage, occurs in only a subset of patients who present with anterior knee pain.5–7
Anatomy and Biomechanics
The patellofemoral joint comprises the patella and the femoral trochlea. The patella acts as a lever and also increases the moment arm of the patellofemoral joint, the quadriceps and patellar tendons.8Contact of the patella with the femur is initiated at 20 degrees of flexion and increases with further knee flexion, reaching a maximum at 90 degrees.9 Stability of the patellofemoral joint involves dynamic and static stabilizers (Figure 1), which control movement of the patella within the trochlea, referred to as “patellar tracking.” Patellar tracking can be altered by imbalances in these stabilizing forces affecting the distribution of forces along the patellofemoral articular surface, the patellar and quadriceps tendons, and the adjacent soft tissues. Forces on the patella range from between one third and one half of a person’s body weight during walking to three times body weight during stair climbing and up to seven times body weight during squatting.10 Abnormalities of patellar tracking must be understood to appreciate the possible causes of PFPS and to determine the focus of treatment.
Figure 1.
Schematic of the right knee, anterior view. Dynamic stability of the patellofemoral joint is provided by the quadriceps tendon, patellar tendon, vastus medialis obliquus (VMO), vastus lateralis, and iliotibial band. The VMO is the only muscle that provides a medial force and is therefore of particular importance in stabilizing the patella. Static stability is provided via the articular capsule, the femoral trochlea, the medial and lateral retinacula, and the patellofemoral ligaments. Palpation of the bony and soft tissue structures should be performed in an attempt to identify the anatomic site of the pain (Table 3).
Risk Factors
Several factors may create a predisposition for the development of PFPS via alterations in patellar tracking, increased patellofemoral joint forces, or combinations of these biomechanical features (Table 1).7,11–15 Overuse, trauma, and anatomic factors appear to be the main contributors.
Lower extremity malalignment (caused by abnormalities such as an increased standing Q angle, pes planus, or subtalar pronation) often has been implicated as a cause of PFPS. However, evidence to support a causal relationship between static measures of lower extremity malalignment and lower extremity injury is limited.11,16,17 In one prospective study, a small subgroup of runners with PFPS was found to have differences in ankle dorsiflexion, genu varum, and forefoot varus compared with noninjured participants.11 Analyses that include a dynamic component may eventually yield more useful information on the role of lower extremity morphology in the development of PFPS.11
Diagnosis
The differential diagnosis of PFPS is summarized in Table 2.12 For most patients, a careful history and physical examination are sufficient to make the diagnosis of PFPS.
HISTORY
Patients with PFPS typically describe pain “behind,” “underneath,” or “around” the patella. The symptoms are usually of gradual onset, although some cases can be caused by trauma, and may be bilateral. Common symptoms include stiffness or pain, or both, on prolonged sitting with the knees flexed (sometimes called the “theater sign”), and pain with activities that load the patellofemoral joint, such as climbing or descending stairs, squatting, or running. The pain can be difficult for the patient to localize. If asked to point to the location of pain, patients may place their hands over the anterior aspect of the knee or draw a circle with their fingers around the patella (the “circle sign”). The pain usually is described as “achy,” but it can be sharp at times. Patients may complain of the knee giving way. This usually does not represent true patellar instability but rather transient inhibition of the quadriceps because of pain or deconditioning.13 However, it is important to determine whether patellar subluxation or dislocation has occurred, because patellar instability can be associated with PFPS. Swelling of the knee is not characteristic of PFPS, although patients may report a sensation of stiffness, especially when the knee is flexed. A “popping” or “catching” sensation may be described. Locking of the joint is not a symptom of PFPS and suggests a meniscal tear or loose bodies. Because PFPS often is related to overuse, recent changes in activities and any changes in the frequency, duration, and intensity of training should be noted. Other possible contributors include inappropriate or excessively worn footwear, and lower extremity resistance training and conditioning activities (particularly squats and lunges). A history of injuries, including patellar subluxation or dislocation, trauma, or surgeries, should be noted because they may cause direct injury to the articular cartilage or alter the forces across the patellofemoral joint, resulting in anterior knee pain.
PHYSICAL EXAMINATION
A complete examination of the knee, including a careful assessment of the patellofemoral joint, should be performed (Table 312,13). The examination should aim to identify features that may alter patellofemoral mechanics.
Inspection. Patients initially should be examined “from the ground up” while standing in shorts. Although the clinical utility of static measurements of lower extremity alignment appears to be limited, such measurements may be performed at this point in the examination. Observation of the patient’s gait may reveal excessive subtalar pronation. Dynamic patellar tracking can be assessed by having the patient perform a single leg squat and stand. Imbalance between the medial and lateral patellar forces (caused by vastus medialis obliquus [VMO] dysfunction or lateral structure tightness) can be manifested by an abrupt medial deviation of the patella as the patella engages the trochlea early in flexion, known as the “J” sign.13 Alternatively, the “J” sign may be observed with the patient supine or seated and the knee extended from a flexed position. Lateral deviation of the patella can be observed during the terminal phase of extension(Figure 2).18
Figure 2.
Lateral patellar tracking (“J” sign). As the knee is extended from 90 degrees flexion (A) to full extension (B), the patella demonstrates an abnormal path, deviating laterally at full extension.18
Quadriceps muscle bulk, especially the VMO, should be assessed by visual inspection and comparison with the opposite side. Measurement of quadriceps muscle girth can be used as a baseline in assessing progress with rehabilitation. Any surgical scars should be noted. Palpation. This portion of the examination should be performed with the patient supine and the knee extended. The knee should be assessed for an effusion. A joint effusion is uncommon in PFPS and should prompt evaluation for other causes of knee pain. Quadriceps muscle tone can be assessed by direct palpation at rest and with isometric contraction. Careful palpation should be performed in an attempt to isolate the location of the pain (Figure 1; Table 312,13). The ligaments also should be examined as part of the comprehensive examination. Range of Motion. Passive and active range of motion of the knee and hip should be assessed. Pain with internal or external rotation of the hip could indicate referred pain resulting from hip joint pathology and should be evaluated further. Patients with PFPS usually demonstrate a full range of motion of the knee. Asymptomatic crepitus with range of motion is a nonspecific finding, although painful crepitus may indicate an articular cartilage injury or osteoarthritis. Special Aspects. Clinical tests for patellar mobility and position, and provocative tests for pain should be performed. The patellar glide (Figure 314), patellar tilt (Figure 418), and patellar grind (Figure 5) tests should be performed as part of the routine assessment of patients with anterior knee pain (Table 312,13). Positive results on these tests are consistent with the diagnosis of PFPS. The patellar apprehension test is used to assess for lateral instability and is positive when pain or discomfort occurs with lateral translation of the patella.
Figure 3.
Patellar mobility testing. Depicted is medial glide testing performed on the right knee. The patella is grasped in the resting position (A), then translated medially (B). The extent of displacement is described in relation to the width of the patella and measured in quadrants (C). Displacement of less than one quadrant medially indicates tightness of the lateral structures. Displacement of more than three quadrants is considered hypermobile.14
Figure 4.
Patellar tilt test. This test assesses for tightness of the lateral structures. The knee is extended and the patella is grasped between the thumb and forefinger. The medial aspect of the patella is then compressed posteriorly while the lateral aspect is elevated. If the lateral aspect of the patella is fixed and cannot be raised to at least the horizontal position (0 degrees), the test is positive and indicates tight lateral structures.18 This also can be seen in patients with patellofemoral osteoarthritis.
Figure 5.
Patellar grind (or inhibition) test. While the patient is in the supine position with the knee extended, the examiner displaces the patella inferiorly into the trochlear groove (pictured). The patient is then asked to contract the quadriceps while the examiner continues to palpate the patella and provides gentle resistance to superior movement of the patella. The test is positive if pain is produced, although comparison to the contralateral knee is needed to interpret the result.
Medial patellar instability can be assessed by displacing the patella medially with the knee extended, then flexing the knee and releasing the patella. Pain indicates medial subluxation.14 Finally, flexibility of the iliotibial band (ITB), quadriceps, hamstrings, hip flexors, and the gastrocnemius should be evaluated. Tightness of the ITB and tightness of the quadriceps have been shown to be risk factors for PFPS.15,19 Poor flexibility in these areas may contribute to stress across the patellofemoral joint, and attention should be directed to this in therapy.
Imaging
PFPS is primarily a clinical diagnosis and, for many patients, treatment can be initiated without imaging. Radiography is an adjunct to the history and physical examination and should be performed in patients with a history of trauma or surgery, those with an effusion, and those whose pain does not improve with treatment. Radiography also may be helpful if a symptomatic bipartite patella is suspected. In persons older than 50 years, radiography should be considered to assess for patellofemoral osteoarthritis. In patients who are skeletally immature, radiography may be helpful to evaluate for other causes of anterior knee pain, such as osteochondritis dissecans, physeal injury, or bone tumors. Other radiographic findings that may mimic PFPS include loose bodies and occult fractures. When indicated, radiography should include the following views: weight-bearing anterior-posterior, weight-bearing true lateral, and axial. The axial view is taken with 20 to 45 degrees of knee flexion. Abnormalities of lateral patellar displacement, lateral patellar tilt, and dysplasia of the trochlea can be assessed on the axial view. Although these findings may indicate malalignment, they also may be seen in asymptomatic patients and are not predictive of outcome.20,21 In symptomatic patients, such findings, in combination with the physical examination, may assist in tailoring treatment. Computed tomography and magnetic resonance imaging (MRI) are not necessary for most patients with PFPS. MRI can be helpful in detecting articular cartilage injuries, chondromalacia patellae, patellar stress fractures, and loose bodies. In addition, a pattern of marrow edema involving the medial aspect of the patella and the lateral aspect of the femoral condyle, and tears of the patellofemoral ligament can be seen with MRI and are suggestive of patellar subluxation or dislocation.
Treatment
The management of PFPS should focus on the implementation of a comprehensive rehabilitation program. It is important to communicate to the patient that a successful return to recreational or competitive activities requires compliance with the rehabilitation plan.
RELATIVE REST
Reduction of loading to the patellofemoral joint and surrounding soft tissues is the first step to reduce pain. If resistance training exercises have been identified as playing a role in causing the injury, cessation of specific exercises such as full squats and lunges is indicated. Runners should reduce mileage to a level that does not provoke pain (while running or the day after running). Alternative activities such as bicycling, swimming, or the use of an elliptical trainer can be used to maintain fitness while treatment is ongoing. Ice or other methods of cold application may further reduce symptoms. Heat is generally not recommended. Patients may find ice application after activity particularly helpful. Although symptoms usually abate with these methods, further treatment is necessary to avoid recurrence.
PHYSICAL THERAPY
A well-structured rehabilitation program is the mainstay of treatment. Several studies have shown physical therapy to be effective in treating PFPS.21–24 However, there is no one program that will be effective for all patients. The rehabilitation program should focus on correcting maltracking of the patella by addressing the findings identified on the physical examination. Some patients may require significant strengthening of the quadriceps. Others may have excellent quadriceps strength but excessively tight lateral structures or poor quadriceps flexibility. Soft tissue techniques and flexibility exercises can be helpful for these patients. A detailed assessment of the imbalances of patellar tracking is therefore essential to tailoring treatment. Specific exercises can then be prescribed as part of a home rehabilitation program. Patients who require further assessment or ongoing instruction can be referred to a physical therapist.
ADDRESSING THE UNDERLYING CAUSE
In most patients with PFPS, a careful history will identify a precipitating event. Changes in activity patterns, such as an increase in running mileage, running stadium steps for conditioning, or the addition of resistance training exercises that affect the patellofemoral joint, often are associated with symptom onset. Excessively worn or inappropriate footwear also may contribute. Discussing these issues with the patient and developing a specific plan to avoid repeating the causal behavior are important in preventing a recurrence.
OTHER TREATMENTS
Analgesics. Although nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for patients with PFPS, there is little evidence supporting their effectiveness.25 NSAIDs or acetaminophen may be considered at the initiation of treatment for patients with symptoms during daily activities and for those whose symptoms are not controlled with ice applications. Bracing. A variety of braces, sleeves, and straps have been used in the treatment of PFPS. Although bracing alone may provide some symptomatic relief, three prospective randomized studies found no significant benefit when bracing was used in addition to physical therapy.26–28 Patellar Taping. Patellar taping has been suggested as a method to treat PFPS by improving alignment and quadriceps function. Although the results from uncontrolled studies were encouraging, the results of three randomized clinical trials have not been consistent: two found no benefit when patellar taping was added to a program of physical therapy.29–31 More studies are needed to determine the role of patellar taping in treating PFPS. Foot Orthoses. As discussed above, prospective studies have yet to demonstrate strong relationships between static measures of lower extremity malalignment and lower extremity injuries. Moreover, alignment was not found to be predictive of outcome in patients with PFPS in two long-term studies.32,33 Other studies, however, have shown that orthoses can be effective in some patients with PFPS.22,34 Over-the-counter soft orthoses are a reasonable choice for patients who have PFPS with malalignment. For those with persistent symptoms, a custom orthotic can be considered.
Long-term Outcomes
There are few long-term studies on the treatment of PFPS. Two studies in which patients were instructed on a program of home exercises reported successful outcomes in approximately 75 to 85 percent of patients with PFPS.33,35 A study of athletes who visited a sports medicine clinic and were instructed on VMO training found that 54 percent were pain free or had mild symptoms after nearly six years.36 Interestingly, arthroscopy findings of the patellar articular surface have not been shown to be predictive of outcome.33 Findings associated with a poorer result include a hypermobile patella, older age, bilateral symptoms, and patellar pain and crepitation on examination.35,36
Surgical Consultation
Surgical consultation for PFPS may be considered for those patients whose symptoms persist despite their completing at least six to 12 months of a thorough program of rehabilitation, and in whom other causes of anterior knee pain have been excluded. Most studies of surgical treatment for patellofemoral disorders are uncontrolled case series. Controlled studies of surgical outcomes are limited and are highly dependent on proper patient selection. Because it is essential that the surgical procedure specifically address the individual characteristics of patellar maltracking in each patient, consultation should be obtained from a surgeon with significant experience in treating patellofemoral joint disorders. Surgical options include release of the lateral retinaculum, articular cartilage procedures, proximal realignment, and distal realignment—often with antero-medialization of the tibial tubercle.14 Patients with tight lateral structures may benefit from lateral release, with proximal realignment in some cases. Distal realignment with anteromedialization of the tibial tubercle may benefit those with lateral compression and associated articular cartilage injury. A full discussion of the various surgical procedures and indications is beyond the scope of this review.
The Authors
SAMEER DIXIT, M.D., is an associate team physician at the University of California, Berkeley. He is a graduate of the University of Maryland School of Medicine, Baltimore, and completed a residency in internal medicine at Northwestern University, Chicago, Ill. Dr. Dixit completed a fellowship in sports medicine at the University of California, Los Angeles (UCLA).
JOHN P. DIFIORI, M.D., FACSM, is associate professor and chief of the Division of Sports Medicine, Department of Family Medicine, at UCLA and a team physician with the UCLA Department of Intercollegiate Athletics. He received his medical degree from Temple University School of Medicine, Philadelphia, Pa. Dr. DiFiori completed a family medicine residency at Lancaster (Pa.) General Hospital and a sports medicine fellowship at UCLA.
MONIQUE BURTON, M.D., is a clinical instructor in the Department of Pediatrics at the University of Washington, Seattle, where she also is a team physician. She is a graduate of Temple University School of Medicine and completed a pediatrics residency at Children’s Hospital and Research Center, Oakland, Calif. Dr. Burton completed a sports medicine fellowship at UCLA.
BRANDON MINES, M.D., is an assistant professor of family medicine and orthopedic surgery at Emory University, Atlanta, Ga. He received his medical degree from the University of Wisconsin in Madison and completed a family medicine residency at St. Luke’s Hospital in Milwaukee, Wis. Dr. Mines completed a sports medicine fellowship at UCLA. He is a team physician for Georgia Institute of Technology, Atlanta.
Author disclosure: Nothing to disclose.
The authors thank Suzanne Hecht, M.D., and Aurelia Nattiv, M.D., for their valuable input in the preparation of this article.
Address correspondence to John P. DiFiori, M.D., UCLA Division of Sports Medicine, 10833 Le Conte Ave., Room 50-080 CHS, Los Angeles, CA 90095. Reprints are not available from the authors.
REFERENCES
1. Taunton JE, Ryan MB, Clement DB, McKenzie DC, Lloyd-Smith DR, Zumbo BD. A retrospective case-control analysis of 2002 running injuries. Br J Sports Med. 2002;36:95–101.
2. Baquie P, Brukner P. Injuries presenting to an Australian sports medicine centre: a 12-month study.Clin J Sport Med. 1997;7:28–31.
3. Garrick JG. Anterior knee pain (chondromalacia patella). Physician Sportsmed. 1989;17:75–84.
4. Clement DB, Taunton JE, Smart GW, McNicol KL. A survey of overuse running injuries. Physician Sportsmed. 1981;9:47–58.
5. Reid DC. The myth, mystic and frustration of anterior knee pain [Editorial]. Clin J Sport Med. 1993;3:139–43.
6. Merchant AC. Classification of patellofemoral disorders. Arthroscopy. 1988;4:235–40.
7. Cutbill JW, Ladly KO, Bray RC, Thorne P, Verhoef M. Anterior knee pain: a review. Clin J Sport Med. 1997;7:40–5.
8. Beynnon BD, Johnson RJ, Coughlin KM. Relevant biomechanics of the knee. In: DeLee JC, Drez D, Miller MD, eds. Orthopaedic Sports Medicine: Principles and Practice. 2nd ed. Philadelphia, Pa.: Saunders, 2003:1590.
9. Fu FH, Seel MJ, Berger RA. Patellofemoral biomechanics. In: Fox JM, Del Pizzo W, eds. The Patellofemoral Joint. New York, N.Y.: McGraw-Hill, 1993:49.
10. Reilly DT, Martens M. Experimental analysis of the quadriceps muscle force and patellofemoral joint reaction force for various activities. Acta Orthop Scand. 1972;43:126–37.
11. Lun V, Meeuwisse WH, Stergiou P, Stefanyshyn D. Relation between running injury and static lower limb alignment in recreational runners. Br J Sports Med. 2004;38:576–80.
12. Brukner P, Khan K, McConnell J, Cook J. Anterior knee pain. In: Brukner P, Khan K. Clinical Sports Medicine. 2nd ed. New York, N.Y.: McGraw-Hill, 2002:464–93.
13. Post WR. Clinical evaluation of patients with patellofemoral disorders. Arthroscopy. 1999;15:841–51.
14. Fulkerson JP. Diagnosis and treatment of patients with patellofemoral pain. Am J Sports Med. 2002;30:447–56.
15. Witvrouw E, Lysens R, Bellemans J, Cambier D, Vanderstraeten G. Intrinsic risk factors for the development of anterior knee pain in an athletic population. A two-year prospective study. Am J Sports Med. 2000;28:480–9.
16. Wen DY, Puffer JC, Schmalzried TP. Injuries in runners: a prospective study of alignment. Clin J Sport Med. 1998;8:187–94.
17. Ilahi OA, Kohl HW III. Lower extremity morphology and alignment and risk of overuse injury. Clin J Sport Med. 1998;8:38–42.
18. Walsh WM. Recurrent dislocation of the knee in the adult. In: DeLee JC, Drez D, Miller MD, eds. Orthopaedic Sports Medicine: Principles and Practice. 2nd ed. Philadelphia, Pa.: Saunders, 2003:1718–21.
19. Doucette SA, Goble EM. The effect of exercise on patellar tracking in lateral patellar compression syndrome. Am J Sports Med. 1992;20:434–40.
20. Elias DA, White LM. Imaging of patellofemoral disorders. Clin Radiol. 2004;59:543–57.
21. Natri A, Kannus P, Jarvinen M. Which factors predict the long-term outcome in chronic patellofemoral pain syndrome? A 7-yr prospective follow-up study. Med Sci Sports Exerc. 1998;30:1572–7.
22. Crossley K, Bennell K, Green S, McConnell J. A systematic review of physical interventions for patellofemoral pain syndrome. Clin J Sport Med. 2001;11:103–10.
23. Crossley K, Bennell K, Green S, Cowan S, McConnell J. Physical therapy for patellofemoral pain: a randomized, double-blinded, placebo-controlled trial. Am J Sports Med. 2002;30:857–65.
24. Witvrouw E, Danneels L, Van Tiggelen D, Willems TM, Cambier D. Open versus closed kinetic chain exercises in patellofemoral pain: a 5-year prospective randomized study. Am J Sports Med. 2004;32:1122–30.
25. Heintjes E, Berger MY, Bierma-Zeinstra SM, Bernsen RM, Verhaar JA, Koes BW. Pharmacotherapy for patellofemoral pain syndrome Cochrane Database Syst Rev. 2004;(3):CD003470.
26. Finestone A, Radin EL, Lev B, Shlamkovitch N, Wiener M, Milgrom C. Treatment of overuse patellofemoral pain. Prospective randomized controlled clinical trial in a military setting. Clin Orthop Relat Res. 1993;293:208–10.
27. Miller MD, Hinkin DT, Wisnowski JW. The efficacy of orthotics for anterior knee pain in military trainees. A preliminary report. Am J Knee Surg. 1997;10:10–3.
28. Lun VM, Wiley JP, Meeuwisse WH, Yanagawa TL. Effectiveness of patellar bracing for treatment of patellofemoral pain syndrome. Clin J Sport Med. 2005;15:235–40.
29. Clark DI, Downing N, Mitchell J, Coulson L, Syzpryt EP, Doherty M. Physiotherapy for anterior knee pain: a randomised controlled trial. Ann Rheum Dis. 2000;59:700–4.
30. Kowall MG, Kolk G, Nuber GW, Cassisi JE, Stern SH. Patellar taping in the treatment of patellofemoral pain. A prospective randomized study. Am J Sports Med. 1996;24:61–6.
31. Whittingham M, Palmer S, Macmillan F. Effects of taping on pain and function in patellofemoral pain syndrome: a randomized controlled trial. J Orthop Sports Phys Ther. 2004;34:504–10.
32. Kannus P, Niittymaki S. Which factors predict outcome in the non-operative treatment of patellofemoral pain syndrome? A prospective follow-up study. Med Sci Sports Exerc. 1994;26:289–96.
33. Karlsson J, Thomee R, Sward L. Eleven year follow-up of patellofemoral pain syndrome. Clin J Sport Med. 1996;6:22–6.
34. Eng JJ, Pierrynowski MR. Evaluation of soft foot orthotics in the treatment of patellofemoral pain syndrome [Published correction appears in Phys Ther 1993;73:330]. Phys Ther. 1993;73:62–70.
35. Kannus P, Natri A, Paakkala T, Jarvinen M. An outcome study of chronic patellofemoral pain syndrome. Seven-year follow-up of patients in a randomized, controlled trial. J Bone Joint Surg Am. 1999;81:355–63.
36. Blond L, Hansen L. Patellofemoral pain syndrome in athletes: a 5.7-year retrospective follow-up study of 250 athletes. Acta Orthop Belg. 1998;64:393–400.
This article is one in a series on sports medicine created in collaboration with the American Medical Society for Sports Medicine. Coordinators of the series are Francis O’Connor, M.D., Virginia Sports Medicine Institute, Fairfax, and Karl (Bert) Fields, M.D., Moses Cone Family Physician Residency and Sports Medicine Fellowship, Greensboro, N.C.